Synthetic control over the dynamics of mesoscaled cargo release from colloidal polymer vectors inside live cells. Issue 2 (22nd July 2014)

• Record Type: Journal Article
• Authors: Chahal, Harvind S.; Chahal, Dev S.; McBride, Patrick M.; Helms, Brett A.
• Is Part Of: Journal of polymer science. Volume 53:Issue 2(2015:Jan.)
• Page Start: 256
• Page End: 264
• Publication Date: 2014-07-22
• Subjects: 547
• DOI: 10.1002/pola.27312
• Languages: English
• ISSNs: 0887-624X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Directed delivery of mesoscaled cargo—for example, nanocrystals, proteins, or nucleic acids—to cells using polymer vectors impacts numerous biomedical fields. We introduce here the concept of dynamic complementarity as a simple, yet powerful approach to control the rate of mesoscaled cargo dissociation from colloidal polymer vectors once inside the cytosol. By tuning the degree of electrostatic reciprocity between the polymer vector and its cargo, it is possible to both deliver and release large cargo in live cells in a controllable manner over both long and short periods, pointing to a highly modular materials platform with molecularly tailored properties suited to task. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. <bold>2015</bold>, <italic>53</italic>, 256–264</p> </abstract>