Consensus guidelines for the treatment of invasive mould infections in haematological malignancy and haemopoietic stem cell transplantation, 2014. Issue 12 (December 2014)

• Record Type: Journal Article
• Authors: Blyth, C. C.; Gilroy, N. M.; Guy, S. D.; Chambers, S. T.; Cheong, E. Y.; Gottlieb, T.; McGuinness, S. L.; Thursky, K. A.
• Is Part Of: Internal medicine journal. Volume 44:Issue 12b(2014)
• Page Start: 1333
• Page End: 1349
• Publication Date: 2014-12
• Subjects: Medicine -- Periodicals; 616
• DOI: 10.1111/imj.12598
• Languages: English
• ISSNs: 1444-0903

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Mould species represent the pathogens most commonly associated with invasive fungal disease in patients with haematological malignancies and patients of haemopoietic stem cell transplants. Invasive mould infections in these patient populations, particularly in the setting of neutropenia, are associated with high morbidity and mortality, and significantly increase the complexity of management. While <italic>A</italic><italic>spergillus</italic> species remain the most prevalent cause of invasive mould infections, <italic>Scedosporium</italic> and <italic>F</italic><italic>usarium</italic> species and the Mucormycetes continue to place a significant burden on the immunocompromised host. Evidence also suggests that infections caused by rare and emerging pathogens are increasing within the setting of broad‐spectrum antifungal prophylaxis and improved survival times placing immunosuppressed patients at risk for longer. These guidelines present evidence‐based recommendations for the antifungal management of common, rare and emerging mould infections in both adult and paediatric populations. Where relevant, the role of surgery, adjunctive therapy and immunotherapy is also discussed.</p> </abstract>