Corpus callosal morphology in youth with bipolar depression. (28th August 2014)

• Record Type: Journal Article
• Authors: MacMaster, Frank P; Langevin, Lisa Marie; Jaworska, Natalia; Kemp, Anne; Sembo, Mariko
• Is Part Of: Bipolar disorders. Volume 16:Number 8(2014)
• Page Start: 889
• Page End: 893
• Publication Date: 2014-08-28
• Subjects: Manic-depressive illness -- Periodicals; Depression, Mental -- Periodicals; 616.895
• DOI: 10.1111/bdi.12247
• Languages: English
• ISSNs: 1398-5647

Abstract

<abstract abstract-type="main" id="bdi12247-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bdi12247-sec-0001" sec-type="section"> <title>Objectives</title> <p>Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structures, including the corpus callosum. Disruptions in white matter integrity have been demonstrated in BD. However, it is unknown whether alterations in the developmental trajectory of the corpus callosum may contribute to cognitive impairments in the disorder.</p> </sec> <sec id="bdi12247-sec-0002" sec-type="section"> <title>Methods</title> <p>We assessed the area of the corpus callosum and its subregions (the genu, rostral body, anterior and posterior bodies, isthmus, and splenium) in 14 treatment‐naïve adolescents with BD (<21 years of age and in the depressed phase) and 18 healthy adolescent controls.</p> </sec> <sec id="bdi12247-sec-0003" sec-type="section"> <title>Results</title> <p>In comparison with healthy controls, participants with BD demonstrated a significantly reduced overall corpus callosum area. We also noted smaller areas in the anterior and posterior mid‐body of the corpus callosum in adolescents with BD.</p> </sec> <sec id="bdi12247-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our results suggest that commissural fibers of the corpus callosum are disrupted in early‐onset BD. Specific decreases in the anterior and posterior mid‐body callosal aspects may contribute to motor organization and inhibition deficits seen in BD. These findings are consistent with the involvement of inter‐hemispheric tracts in early‐onset BD, which may reflect an early deviation in white matter development.</p> </sec> </abstract>