Inhibition of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase increases the expression of interferon‐responsive genes. (December 2014)

• Record Type: Journal Article
• Authors: Yang, Xin; Ouyang, Hongsheng; Chen, Fuwang; Ma, Teng; Dong, Meichen; Wang, Fei; Pang, Daxing; Peng, Zhiyuan; Ren, Linzhu
• Is Part Of: Clinical and experimental pharmacology and physiology. Volume 41:Number 12(2014:Dec.)
• Page Start: 950
• Page End: 955
• Publication Date: 2014-12
• Subjects: Clinical pharmacology -- Periodicals; Pharmacology, Experimental -- Periodicals; Physiology, Experimental -- Periodicals; Physiology, Pathological -- Periodicals; 615.1
• DOI: 10.1111/1440-1681.12299
• Languages: English
• ISSNs: 0305-1870

Abstract

<abstract abstract-type="main" id="cep12299-abs-0001"> <title>Summary</title> <p>The 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) pathway is an important metabolic route that is present in almost every organism. However, whether HMGCR affects the expression of interferon (IFN)‐responsive genes is unclear. In the present study, expression levels of IFN‐responsive genes were monitored by real time polymerase chain reaction and enzyme‐linked immunosorbent assay. The results showed that expression levels of IFN‐responsive genes were significantly increased in HMGCR‐downregulated cells and HMGCR inhibitor‐treated cells, indicating that inhibition of HMGCR activates the expression of IFN‐responsive genes. The result in this study will provide new insight into the role of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase in antiviral research.</p> </abstract>