Maternal 25‐hydroxyvitamin D level and fetal bone growth assessed by ultrasound: a systematic review. (December 2014)

• Record Type: Journal Article
• Authors: Galthen‐Sørensen, M.; Andersen, L. B.; Sperling, L.; Christesen, H. T.
• Is Part Of: Ultrasound in obstetrics & gynecology. Volume 44:Number 6(2014:Dec.)
• Page Start: 633
• Page End: 640
• Publication Date: 2014-12
• Subjects: Ultrasonics in obstetrics -- Periodicals; Generative organs, Female -- Diseases -- Diagnosis -- Periodicals; Diagnosis, Ultrasonic -- Periodicals; Genital Diseases, Female -- ultrasonography -- Periodicals; Ultrasonography, Prenatal -- Periodicals; 618.047543
• DOI: 10.1002/uog.13431
• Languages: English
• ISSNs: 0960-7692

Abstract

<abstract abstract-type="main" id="uog13431-abs-0001"> <title>ABSTRACT</title> <sec id="uog13431-sec-0001" sec-type="section"> <title>Objectives</title> <p id="uog13431-para-0001">To assess systematically the role of maternal vitamin D levels in fetal bone growth.</p> </sec> <sec id="uog13431-sec-0002" sec-type="section"> <title>Methods</title> <p id="uog13431-para-0002">PubMed, EMBASE and Cochrane databases were searched using the search words [Vitamin D] in combination with [fetal, fetus, intrauterine, or prenatal AND growth, development, bone, femur, or humerus]; [crown–rump length]; or [ultrasonography, prenatal]. Criteria for inclusion in this systematic review were data on maternal serum 25‐hydroxyvitamin D (25(OH)D) during pregnancy and measurement of fetal growth by ultrasound.</p> </sec> <sec id="uog13431-sec-0003" sec-type="section"> <title>Results</title> <p id="uog13431-para-0003">We identified 750 publications initially, from which five observational studies were selected for inclusion in the final review. The parameters studied were humerus length (HL) and femur length (FL) and their <italic>Z</italic>‐scores, femoral volume, femoral distal metaphyseal cross‐sectional area (CSA), femoral proximal metaphyseal diameter (PMD), femoral mid‐shaft diameter and crown–rump length. In one study, 25(OH)D was associated directly with FL; in another study 25(OH)D only correlated with FL and HL <italic>Z</italic>‐scores when calcium intake was insufficient. Two studies found no association between 25(OH)D and FL, but detected a direct association with femoral PMD, and an inverse relation with femoral distal metaphyseal CSA, respectively.</p> </sec> <sec id="uog13431-sec-0004" sec-type="section"> <title>Conclusions</title> <p id="uog13431-para-0004">Observational studies investigating the role of maternal vitamin D levels in fetal bone growth are sparse. Their evidence suggests that low maternal 25(OH)D levels may affect fetal bone growth under certain circumstances, especially in cases of simultaneous low calcium intake. Further studies are necessary. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.</p> </sec> </abstract>