Linking cancer genome to proteome: NCI's investment into proteogenomics. Issue 23 (18th October 2014)

• Record Type: Journal Article
• Authors: Rivers, Robert C.; Kinsinger, Christopher; Boja, Emily S.; Hiltke, Tara; Mesri, Mehdi; Rodriguez, Henry; Pandey, Akhilesh; Pevzner, Pavel A.
• Is Part Of: Proteomics. Volume 14:Issue 23/24(2014)
• Page Start: 2633
• Page End: 2636
• Publication Date: 2014-10-18
• Subjects: Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201400193
• Languages: English
• ISSNs: 1615-9853

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Advances in both targeted and unbiased MS‐based proteomics are now at a mature stage for comprehensively and reproducibly characterizing a large part of the cancer proteome. These developments combined with the extensive genomic characterization of several cancer types by large‐scale initiatives such as the International Cancer Genome Consortium and Cancer Genome Atlas Project have paved the way for proteogenomic analysis of omics datasets and integration methods. The advances serve as the basis for the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium and this article highlights its current work and future steps in the area of proteogenomics.</p> </abstract>