Sequential Rhodium/Palladium Catalysis: Enantioselective Formation of Dihydroquinolinones in the Presence of Achiral and Chiral Ligands1. Issue 50 (24th September 2014)

• Record Type: Journal Article
• Authors: Zhang, Lei; Qureshi, Zafar; Sonaglia, Lorenzo; Lautens, Mark
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 50(2014)
• Page Start: 13850
• Page End: 13853
• Publication Date: 2014-09-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201407400
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Compatible combinations of achiral and chiral ligands can be used in rhodium/palladium catalysis to achieve highly enantioselective domino reactions. The difference in rates of catalysis and minimal effects of ligand interference confer control in the domino sequence. The "all‐in‐one" 1, 4‐conjugate arylation and CN cross‐coupling through sequential Rh/Pd catalysis provides access to enantioenriched dihydroquinolinone building blocks.</p> </abstract>