Iron(III) Chloride Catalyzed Synthesis of Highly Substituted Indolyl‐Tetrahydroquinoline Derivatives by Using Indolylnitroalkene as Dienophiles and Its Application to the Synthesis of Indolo‐Benzonaphthyridine Derivatives. Issue 18 (4th November 2014)

• Record Type: Journal Article
• Authors: Zanwar, Manoj R.; Gawande, Sachin D.; Kavala, Veerababurao; Kuo, Chun‐Wei; Yao, Ching‐Fa
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 18(2014)
• Page Start: 3849
• Page End: 3860
• Publication Date: 2014-11-04
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400424
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An efficient iron(III) chloride catalyzed synthesis of highly substituted indolyltetrahydroquinoline derivatives from easily available starting materials, including indolylnitroalkenes, substituted anilines and various aldehydes is reported. The reaction utilized strong electron deficient dienophiles like indolylnitroalkene <italic>via</italic> a Povarov approach.</p> <p>The methodology shows good functional group tolerance and can be used to prepare fused indolo‐benzonaphthyridine derivatives.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2qst2t9k" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>