Synthesis of Aminonaphthopyranones and Aminonaphthochromenones by Blaise‐Reaction‐Initiated Cascade Procedures. Issue 12 (5th October 2014)

• Record Type: Journal Article
• Authors: He, Yan; Zhang, Xinying; Fan, Xuesen
• Is Part Of: Asian journal of organic chemistry. Volume 3:Issue 12(2014:Dec.)
• Page Start: 1284
• Page End: 1291
• Publication Date: 2014-10-05
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201402173
• Languages: English
• ISSNs: 2193-5807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An efficient one‐pot synthesis of aminonaphthopyranones through the tandem reaction of 2‐(4‐hydroxybut‐1‐ynyl)benzonitriles with Reformatsky reagents has been developed. Using a similar strategy, aminonaphthochromenones were obtained smoothly starting from 2‐[(2‐hydroxyphenyl)ethynyl]benzonitriles. Furthermore, by taking advantage of the versatile reactivity of the amino group, structural manipulations of aminonaphthopyranone were readily undertaken to give naphthopyranone, 10‐hydroxynaphthopyranone and a functionalized 1, 1′‐binaphthyl of potential interest for synthetic and medicinal chemistry studies.</p> </abstract>