Applications of Synchrotron‐Based Spectroscopic Techniques in Studying Nucleic Acids and Nucleic Acid‐Functionalized Nanomaterials. (10th September 2014)

• Record Type: Journal Article
• Authors: Wu, Peiwen; Yu, Yang; McGhee, Claire E.; Tan, Li Huey; Lu, Yi
• Is Part Of: Advanced materials. Volume 26:Number 46(2014)
• Page Start: 7849
• Page End: 7872
• Publication Date: 2014-09-10
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201304891
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In this review, we summarize recent progress in the application of synchrotron‐based spectroscopic techniques for nucleic acid research that takes advantage of high‐flux and high‐brilliance electromagnetic radiation from synchrotron sources. The first section of the review focuses on the characterization of the structure and folding processes of nucleic acids using different types of synchrotron‐based spectroscopies, such as X‐ray absorption spectroscopy, X‐ray emission spectroscopy, X‐ray photoelectron spectroscopy, synchrotron radiation circular dichroism, X‐ray footprinting and small‐angle X‐ray scattering. In the second section, the characterization of nucleic acid‐based nanostructures, nucleic acid‐functionalized nanomaterials and nucleic acid‐lipid interactions using these spectroscopic techniques is summarized. Insights gained from these studies are described and future directions of this field are also discussed.</p> </abstract>