Laminations and Microgranule Formation in Pediatric Glomerular Basement Membranes. (1st October 2014)

• Record Type: Journal Article
• Authors: Craver, Randall; Crespo-Salgado, Janice; Aviles, Diego
• Is Part Of: Fetal and pediatric pathology. Volume 33:Number 5/6(2014)
• Page Start: 321
• Page End: 330
• Publication Date: 2014-10-01
• Subjects: Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2014.976686
• Languages: English
• ISSNs: 1551-3815

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Glomerular basement membrane (GBM) splitting, laminations, and microgranular formation are classically encountered with Alport disease, but can be found in other glomerular diseases. We found moderate to marked GBM laminations/microgranular formations in 51 of 724 (7%) pediatric diagnostic renal biopsies. These included 12 Alport disease, 12 thin basement membrane disease (TBM), 13 mesangial hypercellularity (MH), 6 focal segmental glomerulosclerosis (FSGS), and 8 other diseases. Follow-up demonstrated progression in most of the Alport disease and FSGS, as expected, but also in 40% of TBM and 30% of MH. Basement membrane laminations/microgranular formations are not specific for Alport disease, may represent a non-specific injury, and may herald a progressive clinical course.</p> </abstract>