Protein Traffic to the Plasmodium falciparum Apicoplast: Evidence for a Sorting Branch Point at the Golgi. (15th October 2014)

• Record Type: Journal Article
• Authors: Heiny, Sabrina R.; Pautz, Sabine; Recker, Mario; Przyborski, Jude M.
• Is Part Of: Traffic. Volume 15:Number 12(2014:Dec.)
• Page Start: 1290
• Page End: 1304
• Publication Date: 2014-10-15
• Subjects: Biological transport -- Periodicals; 571.6
• DOI: 10.1111/tra.12226
• Languages: English
• ISSNs: 1398-9219

Abstract

<abstract abstract-type="short" id="tra12226-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="tra12226-para-0001"> <italic>Plasmodium falciparum</italic>, similar to many other apicomplexan parasites, contains an apicoplast, a plastid organelle of secondary endosymbiotic origin. Nuclear‐encoded proteins are posttranslationally transported to the apicoplast via the endoplasmic reticulum. However, it has long been a matter of contention if the Golgi also plays a role in this process. In this study, we show that trafficking to the apicoplast occurs via the Golgi as an intermediate compartment. Our data suggest that the <italic>Plasmodium</italic> Golgi has an important function as a protein sorting compartment.</p> </abstract>