Two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS. (20th October 2014)

• Record Type: Journal Article
• Authors: Hiraki, Tsubasa; Yoshimitsu, Makoto; Suzuki, Tadaki; Goto, Yuko; Higashi, Michiyo; Yokoyama, Seiya; Tabuchi, Tomohisa; Futatsuki, Takahiro; Nakamura, Kentaro; Hasegawa, Hideki; Saijo, Masayuki; Kakihana, Yasuyuki; Arima, Naomichi; Yonezawa, Suguru
• Is Part Of: Pathology international. Volume 64:Number 11(2014:Nov.)
• Page Start: 569
• Page End: 575
• Publication Date: 2014-10-20
• Subjects: Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12207
• Languages: English
• ISSNs: 1320-5463

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We report two autopsy cases of severe fever with thrombocytopenia syndrome (SFTS) with a high fatality rate in aged Japanese patients. Both cases were caused by a tick‐bite. The pathognomonic histological feature was necrotizing lymphadenitis of systemic lymphoid tissue with SFTS viruses and SFTSV‐RNA copies. Marked fungal infections were also observed in the lungs of both patients. Since cellular immune function may be suppressed in SFTS patients, physicians should be aware of possible fungal infections.</p> </abstract>