A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China. Issue 6 (1st November 2014)

• Record Type: Journal Article
• Authors: Fan, Shengtao; Zhou, Lichen; Wu, Di; Gao, Xiaolong; Pei, Enle; Wang, Tianhou; Gao, Yuwei; Xia, Xianzhu
• Is Part Of: Influenza and other respiratory viruses. Volume 8:Issue 6(2014:Nov.)
• Page Start: 646
• Page End: 653
• Publication Date: 2014-11-01
• Subjects: Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12289
• Languages: English
• ISSNs: 1750-2640

Abstract

<abstract abstract-type="main" id="irv12289-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Migrating wild birds are considered natural reservoirs of influenza viruses and serve as a potential source of novel influenza strains in humans and livestock. During routine avian influenza surveillance conducted in eastern China, a novel H5N8 (SH‐9) reassortant influenza virus was isolated from a mallard duck in China. <sc>blast</sc> analysis revealed that the HA, NA, PB1, PA, NP, and M segments of SH‐9 were most closely related to the corresponding segments of A/duck/Jiangsu/k1203/2010 (H5N8). The SH‐9 virus preferentially recognized avian‐like influenza virus receptors and was highly pathogenic in mice. Our results suggest that wild birds could acquire the H5N8 virus from breeding ducks and spread the virus via migratory bird flyways.</p> </abstract>