A possible role of serum uric acid as a marker of metabolic syndrome. Issue 12 (December 2014)

• Record Type: Journal Article
• Authors: Lee, Y.‐J.; Cho, S.; Kim, S. R.
• Is Part Of: Internal medicine journal. Volume 44:Issue 12a(2014)
• Page Start: 1210
• Page End: 1216
• Publication Date: 2014-12
• Subjects: Medicine -- Periodicals; 616
• DOI: 10.1111/imj.12588
• Languages: English
• ISSNs: 1444-0903

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="imj12588-sec-0001" sec-type="section"> <title>Background/Aims</title> <p>The association between serum uric acid (SUA) levels and metabolic syndrome (MetS) has recently been reported in several cross‐sectional and longitudinal studies. We investigated SUA as a biomarker to predict future development of MetS in healthy Korean men without diabetes or hypertension and determined the optimal cut‐off levels of SUA.</p> </sec> <sec id="imj12588-sec-0002" sec-type="section"> <title>Methods</title> <p>A retrospective cohort study was conducted using data from healthy men who received a general health check‐up in 2003. A total of 1809 participants free of MetS, diabetes and hypertension was enrolled. Participants were classified into three groups based on SUA levels: group 1 (<5.5 mg/dL), group 2 (5.5–6.9 mg/dL) and group 3 (≥7.0 mg/dL).</p> </sec> <sec id="imj12588-sec-0003" sec-type="section"> <title>Results</title> <p>During 13 802 person‐years of follow up, 127 participants developed MetS. After adjusting for multiple associated parameters, SUA was significantly associated with incident MetS (hazard ratios comparing groups 2 and 3 vs group 1, 2.45 and 3.47 respectively; <italic>P</italic> < 0.001). In receiver operating characteristic curve analysis, the optimal cut‐off level for SUA to predict the development of MetS was 6.5 mg/dL.</p> </sec> <sec id="imj12588-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our results indicate that an increased level of SUA, even within the normal range, is associated with future development of MetS in healthy middle‐aged men.</p> </sec> </abstract>