Does the multidisciplinary approach improve oncological outcomes in men undergoing surgical treatment for prostate cancer?. (14th July 2014)

• Record Type: Journal Article
• Authors: Stewart, Suzanne B; Moul, Judd W; Polascik, Thomas J; Koontz, Bridget F; Robertson, Cary N; Freedland, Stephen J; George, Daniel J; Lee, W Robert; Armstrong, Andrew J; Bañez, Lionel L
• Is Part Of: International journal of urology. Volume 21:Number 12(2014)
• Page Start: 1215
• Page End: 1219
• Publication Date: 2014-07-14
• Subjects: Urology -- Periodicals; Genitourinary organs -- Periodicals; Urologic Diseases -- Periodicals; 616.6005
• DOI: 10.1111/iju.12561
• Languages: English
• ISSNs: 0919-8172

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="iju12561-sec-0001" sec-type="section"> <title>Objectives</title> <p>To determine whether oncological outcomes are improved in prostate cancer patients by using a multidisciplinary strategy as compared with a standard clinic paradigm, and whether time to treatment is delayed when using a multidisciplinary approach.</p> </sec> <sec id="iju12561-sec-0002" sec-type="section"> <title>Methods</title> <p>We retrospectively analyzed patients who were evaluated and pursued radical prostatectomy as primary treatment, by the same surgeons, in the prostate cancer multidisciplinary clinic (<italic>n</italic> = 194) and standard urology clinic (<italic>n</italic> = 741) at Duke University Medical Center from 2005 to 2009. Comparisons of baseline characteristics were examined using rank sum and χ<sup>2</sup>‐tests. Differences in time to radical prostatectomy and oncological outcomes were evaluated using multivariate linear and Cox regression, respectively.</p> </sec> <sec id="iju12561-sec-0003" sec-type="section"> <title>Results</title> <p>A greater proportion of high‐risk patients (D'Amico criteria) were evaluated at the multidisciplinary clinic compared with the urology clinic (23.2% <italic>vs</italic> 15.6%, <italic>P</italic> = 0.014). Mean‐adjusted time from biopsy to radical prostatectomy was shorter for multidisciplinary clinic patients (85.6 <italic>vs</italic> 96.8 days, <italic>P</italic> = 0.006). After a median follow up of 21 months, no significant difference was found between the multidisciplinary clinic and urology clinic in the risk of biochemical recurrence after radical prostatectomy, whether controlling for clinical (hazard ratio 0.71, <italic>P</italic> = 0.249) or pathological variables (hazard ratio 0.75, <italic>P</italic> = 0.349).</p> </sec> <sec id="iju12561-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Despite higher‐risk disease, men evaluated using the multidisciplinary approach have similar oncological outcomes compared with men undergoing standard evaluation. Furthermore, time to radical prostatectomy is not delayed by the multidisciplinary management of these patients.</p> </sec> </abstract>