Kava dermopathy in Fiji: an acquired ichthyosis?. (29th July 2014)

• Record Type: Journal Article
• Authors: Hannam, Sarah; Murray, Michael; Romani, Lucia; Tuicakau, Meciusela; J Whitfeld, Margot
• Is Part Of: International journal of dermatology. Volume 53:Number 12(2014:Dec.)
• Page Start: 1490
• Page End: 1494
• Publication Date: 2014-07-29
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.12546
• Languages: English
• ISSNs: 0011-9059

Abstract

<abstract abstract-type="main" id="ijd12546-abs-0001"> <title>Summary</title> <p>Kava dermopathy is a common cutaneous effect of regular or heavy use of Kava, a psychoactive beverage consumed widely throughout the Pacific. In Fiji in 2012, over 1000 study participants underwent full skin examination, and kava dermopathy was a common cutaneous finding. The clinical manifestations of kava dermopathy share similarities with the spectrum of autosomal recessive congenital ichthyoses, predominantly lamellar ichthyosis. The pathogenesis of Kava dermopathy may be associated with a functional defect in one or more cytochrome P450 enzymes implicated in epidermal integrity, thus mimicking the genetic defect as seen in lamellar ichthyosis type 3.</p> </abstract>