External validation of European Organization for Research and Treatment of Cancer and Spanish Urological Club for Oncological Treatment scoring models to predict recurrence and progression in Japanese patients with non‐muscle invasive bladder cancer treated with bacillus Calmette–Guérin. (30th July 2014)

• Record Type: Journal Article
• Authors: Kohjimoto, Yasuo; Kusumoto, Hiroki; Nishizawa, Satoshi; Kikkawa, Kazuro; Kodama, Yoshiki; Ko, Motohiro; Matsumura, Nagahide; Hara, Isao
• Is Part Of: International journal of urology. Volume 21:Number 12(2014)
• Page Start: 1201
• Page End: 1207
• Publication Date: 2014-07-30
• Subjects: Urology -- Periodicals; Genitourinary organs -- Periodicals; Urologic Diseases -- Periodicals; 616.6005
• DOI: 10.1111/iju.12572
• Languages: English
• ISSNs: 0919-8172

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="iju12572-sec-0001" sec-type="section"> <title>Objective</title> <p>To validate two prediction models (European Organization for Research and Treatment of Cancer and Spanish Urological Club for Oncological Treatment) for recurrence and progression of non‐muscle invasive bladder cancer in Japanese patients who underwent bacillus Calmette–Guérin instillation therapy.</p> </sec> <sec id="iju12572-sec-0002" sec-type="section"> <title>Methods</title> <p>From March 1985 to April 2007, data were analyzed from 366 patients who underwent transurethral resection of bladder tumor followed by bacillus Calmette–Guérin instillation therapy. The ability of two scoring models to predict recurrence and progression was assessed by concordance index.</p> </sec> <sec id="iju12572-sec-0003" sec-type="section"> <title>Results</title> <p>For recurrence probability, the concordance index of the European Organization for Research and Treatment of Cancer and Spanish Urological Club for Oncological Treatment models was 0.514 and 0.576, respectively, which was lower than that (0.604) of a selected single prognostic factor (age) by our multivariate analysis. For progression probability, the concordance index of European Organization for Research and Treatment of Cancer and Spanish Urological Club for Oncological Treatment models was 0.693 and 0.764, respectively, which was higher than that (0.633) of a selected single factor (T stage) by our multivariate analysis. The Spanish Urological Club for Oncological Treatment scoring system resulted in better stratification of tumor recurrence and progression when compared with the European Organization for Research and Treatment of Cancer model, probably because more patients underwent bacillus Calmette–Guérin treatment in the Spanish Urological Club for Oncological Treatment cohort than in the European Organization for Research and Treatment of Cancer cohort.</p> </sec> <sec id="iju12572-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The Spanish Urological Club for Oncological Treatment scoring system is a good predictor of tumor recurrence and progression in Japanese patients who underwent bacillus Calmette–Guérin immunotherapy. A large prospective study is warranted to confirm the efficacy of this system.</p> </sec> </abstract>