ATF4 activity: a common feature shared by many kinds of slow‐aging mice. Issue 6 (26th August 2014)

• Record Type: Journal Article
• Authors: Li, Weiquan; Li, Xinna; Miller, Richard A.
• Is Part Of: Aging cell. Volume 13:Issue 6(2014:Dec.)
• Page Start: 1012
• Page End: 1018
• Publication Date: 2014-08-26
• Subjects: Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.12264
• Languages: English
• ISSNs: 1474-9718

Abstract

<abstract abstract-type="main" id="acel12264-abs-0001"> <title>Summary</title> <p>ATF4, a DNA‐binding factor that modulates responses to amino acid availability and ribosomal function, has been shown to be altered in both liver and fibroblasts from two strains of long‐lived mice, i.e. Snell dwarf and PAPP‐A knockout mice. New data now show elevated ATF4 levels, and elevation of ATF4‐dependent proteins and mRNAs, in liver of mice treated with acarbose or rapamycin, calorically restricted mice, methionine‐restricted mice, and mice subjected to litter crowding. Elevation of ATF4, at least in liver, thus seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan in mice.</p> </abstract>