Mesoporous Silica Supraparticles for Sustained Inner‐Ear Drug Delivery. Issue 21 (5th August 2014)

• Record Type: Journal Article
• Authors: Wang, Yajun; Wise, Andrew K.; Tan, Justin; Maina, James W.; Shepherd, Robert K.; Caruso, Frank
• Is Part Of: Small. Volume 10:Issue 21(2014:Nov.)
• Page Start: 4244
• Page End: 4248
• Publication Date: 2014-08-05
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201401767
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="smll201401767-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Mesoporous silica supraparticles</bold> (MS‐SPs) are prepared via self‐assembly of mesoporous silica nanoparticles under capillary force action in confined droplets. The MS‐SPs are effective carriers for sustained drug delivery. Animal studies show that these particles are suitable for chronic intracochlear implantation, and neurotrophins released from the MS‐SPs can efficiently rescue primary auditory neurons in an in vivo sensorineural hearing loss model. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2cqppwt5" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>