Cancer Therapy: Folic Acid Functionalized Surface Highlights 5‐Methylcytosine‐Genomic Content within Circulating Tumor Cells (Small 21/2014). Issue 21 (November 2014)

• Record Type: Journal Article
• Authors: Malara, Natalia; Coluccio, Maria Laura; Limongi, Tania; Asande, Monica; Trunzo, Valentina; Cojoc, Gheorghe; Raso, Cinzia; Candeloro, Patrizio; Perozziello, Gerardo; Raimondo, Raffaella; De Vitis, Stefania; Roveda, Laura; Renne, Maria; Prati, Ubaldo; Mollace, Vincenzo; Di Fabrizio, Enzo
• Is Part Of: Small. Volume 10:Issue 21(2014:Nov.)
• Page Start: 4412
• Page End: 4412
• Publication Date: 2014-11
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201470135
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="smll201470135-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A folic acid (FA)‐functionalized surface, able to selectively entrap circulating tumor cell (CTC)‐expressing folic receptors, is developed by E. Di Fabrizio and co‐workers on page 4324. Since FA represents a good transducer highlighting the CTC global 5‐methylcytosine content, this functionalized surface represents an important tool to profile cellular methylation changes in tumor monitoring strategies. The image shows CTCs under a scanning electron microscope after fixation and metallization. Image credit: M. Orlando, R. Ruffilli, and V. Shalabaeva. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2cqpq1fn" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>