Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near‐Infra‐Red Light. (14th July 2014)

• Record Type: Journal Article
• Authors: Forbes, Natalie; Pallaoro, Alessia; Reich, Norbert O.; Zasadzinski, Joseph A.
• Is Part Of: Particle and particle systems characterization. Volume 31:Number 11(2014:Nov.)
• Page Start: 1158
• Page End: 1167
• Publication Date: 2014-07-14
• Subjects: Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201400035
• Languages: English
• ISSNs: 0934-0866

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A novel drug carrier is presented consisting of plasmonic hollow gold nanoshells (HGN) chemically tethered to liposomes made temperature sensitive with lysolipids (TSL). Continuous‐wave irradiation by physiologically friendly near‐infra‐red light at 800 nm for 2.5 min at laser intensities an order of magnitude below that known to damage skin generates heating localized to the liposome membrane. The heating increases the liposome permeability in an irradiation dose dependent, but reversible manner, resulting in rapid release of small molecules such as the self‐quenching dye carboxyfluorescein or the chemotherapeutic doxorubicin, without raising the bulk temperature. The local rise in nanoshell temperature under laser irradiation is inferred by comparing dye release rates from the TSL via bulk heating to that induced by irradiation. Laser‐irradiation of TSL enables precise control of contents release with low temperature gradients confined to areas irradiated by the laser focus. The combined effects of rapid local release and localized hyperthermia provide a synergistic effect as shown by a near doubling of androgen resistant PPC‐1 prostate cancer cell toxicity compared to the same concentration of free doxorubicin.</p> </abstract>