Metabolomic profiles and childhood obesity. (24th September 2014)

• Record Type: Journal Article
• Authors: Perng, Wei; Gillman, Matthew W.; Fleisch, Abby F.; Michalek, Ryan D.; Watkins, Steven M.; Isganaitis, Elvira; Patti, Mary‐Elizabeth; Oken, Emily
• Is Part Of: Obesity. Volume 22:Number 12(2014:Dec.)
• Page Start: 2570
• Page End: 2578
• Publication Date: 2014-09-24
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20901
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20901-sec-0001" sec-type="section"> <title>Objective</title> <p>To identify metabolite patterns associated with childhood obesity, to examine relations of these patterns with measures of adiposity and cardiometabolic risk, and to evaluate associations with maternal peripartum characteristics.</p> </sec> <sec id="oby20901-sec-0002" sec-type="section"> <title>Methods</title> <p>Untargeted metabolomic profiling was used to quantify metabolites in plasma of 262 children (6‐10 years). Principal components analysis was used to consolidate 345 metabolites into 18 factors and identified two that differed between obese (BMI ≥ 95<bold>‰</bold>; <italic>n</italic> = 84) and lean children (BMI < 85‰; <italic>n</italic> = 150). The relations of these factors with adiposity (fat mass, BMI, skinfold thicknesses) and cardiometabolic biomarkers (HOMA‐IR, triglycerides, leptin, adiponectin, hsCRP, IL‐6) using multivariable linear regression was then investigated. Finally, the associations of maternal prepregnancy obesity, gestational weight gain, and gestational glucose tolerance with the offspring metabolite patterns was examined.</p> </sec> <sec id="oby20901-sec-0003" sec-type="section"> <title>Results</title> <p>A branched‐chain amino acid (BCAA)‐related pattern and an androgen hormone pattern were higher in obese vs. lean children. Both patterns were associated with adiposity and worse cardiometabolic profiles. For example, each increment in the BCAA and androgen pattern scores corresponded with 6% (95% CI: 1, 13%) higher HOMA‐IR. Children of obese mothers had 0.61 (0.13, 1.08) higher BCAA score than their counterparts.</p> </sec> <sec id="oby20901-sec-0004" sec-type="section"> <title>Conclusions</title> <p>BCAA and androgen metabolites were associated with adiposity and cardiometabolic risk during mid‐childhood. Maternal obesity may contribute to altered offspring BCAA metabolism.</p> </sec> </abstract>