Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: The CARDIA study. (13th August 2014)

• Record Type: Journal Article
• Authors: Reis, Jared P.; Allen, Norrina; Gibbs, Bethany B.; Gidding, Samuel S.; Lee, Joyce M.; Lewis, Cora E.; Lima, Joao; Lloyd‐Jones, Donald; Loria, Catherine M.; Powell‐Wiley, Tiffany M.; Sharma, Shishir; Wei, Gina; Liu, Kiang
• Is Part Of: Obesity. Volume 22:Number 11(2014:Nov.)
• Page Start: 2434
• Page End: 2440
• Publication Date: 2014-08-13
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20865
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20865-sec-0001" sec-type="section"> <title>Objective</title> <p>Examine whether there are independent influences of a greater degree of adiposity and longer duration of obesity on cardiac structure and function.</p> </sec> <sec id="oby20865-sec-0002" sec-type="section"> <title>Methods</title> <p>Participants of CARDIA were 18‐30 years when they underwent a baseline examination in 1985‐86. Seven follow‐up examinations were conducted every 2‐5 years.</p> </sec> <sec id="oby20865-sec-0003" sec-type="section"> <title>Results</title> <p>Among 2, 547 participants who underwent an echocardiogram at the year 25 examination and were not obese at baseline, 34.4 and 35.5% were overall (BMI ≥ 30 kg m<sup>−2</sup>) and abdominally obese (waist circumference: men: >102 cm; women: >88 cm) at year 25, respectively. A greater degree of overall and abdominal adiposity at year 25 were each associated with a greater left ventricular (LV) mass (<italic>P</italic> < 0.001), LV volume (<italic>P</italic> < 0.001), LV mass‐to‐volume ratio (<italic>P</italic> < 0.001), left atrial dimension (<italic>P</italic> < 0.001), and ejection fraction (<italic>P</italic> < 0.05) after adjustment for duration of obesity and other risk factors. In contrast, a longer duration of overall obesity was associated with a greater LV mass (<italic>P</italic> = 0.003) and a trend for a lower ejection fraction (<italic>P</italic> = 0.07).</p> </sec> <sec id="oby20865-sec-0004" sec-type="section"> <title>Conclusions</title> <p>A greater degree of adiposity is strongly associated with concentric LV remodeling in midlife, while the cumulative effects of a longer duration of overall obesity during young adulthood contribute to concentric remodeling predominantly by increasing LV mass.</p> </sec> </abstract>