31P MR spectroscopic imaging combined with 1H MR spectroscopic imaging in the human prostate using a double tuned endorectal coil at 7T. Issue 6 (19th December 2013)

• Record Type: Journal Article
• Authors: Luttje, Mariska P.; Italiaander, Michel G. M.; Arteaga de Castro, Catalina S.; van der Kemp, Wybe J. M.; Luijten, Peter R.; van Vulpen, Marco; van der Heide, Uulke A.; Klomp, Dennis W. J.
• Is Part Of: Magnetic resonance in medicine. Volume 72:Issue 6(2014:Dec.)
• Page Start: 1516
• Page End: 1521
• Publication Date: 2013-12-19
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25070
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25070-sec-0001" sec-type="section"> <title>Purpose</title> <p>Improved diagnostic sensitivity could be obtained in cancer detection and staging when individual compounds of the choline pool can be detected. Therefore, a novel coil design is proposed, providing the ability to acquire both <sup>1</sup>H and <sup>31</sup>P magnetic resonance spectroscopic imaging (MRSI) in patients with prostate cancer.</p> </sec> <sec id="mrm25070-sec-0002" sec-type="section"> <title>Methods</title> <p>A two‐element <sup>1</sup>H/<sup>31</sup>P endorectal coil was designed by adjusting a commercially available 3T endorectal coil. The two‐element coil setup was interfaced as a transceiver to a whole body 7T MR scanner. Simulations and phantom measurements were performed to compare the efficiency of the coil. <sup>1</sup>H MRSI and <sup>31</sup>P MRSI were acquired in vivo in prostate cancer patients.</p> </sec> <sec id="mrm25070-sec-0003" sec-type="section"> <title>Results</title> <p>The efficiency of the <sup>1</sup>H/<sup>31</sup>P coil is comparable to the dual channel <sup>1</sup>H coil previously published. Individually distinguishable phospholipid metabolites in the in vivo <sup>31</sup>P spectra were: phosphoethanolamine, phosphocholine, phosphate, glycerophosphoethanolamine, glycerophosphocholine, phosphocreatine, and adenosine triposphate. <sup>1</sup>H MRSI was performed within the same scan session, visualizing choline, polyamines, creatine, and citrate.</p> </sec> <sec id="mrm25070-sec-0004" sec-type="section"> <title>Conclusion</title> <p> <sup>1</sup>H MRSI and <sup>31</sup>P MRSI can be acquired in the human prostate at 7T within the same scan session using an endorectal coil matched and tuned for <sup>1</sup>H (quadrature) and <sup>31</sup>P (linear) without the need of cable traps and with negligible efficiency losses in the <sup>1</sup>H and <sup>31</sup>P channel. Magn Reson Med 72:1516–1521, 2014. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>