Metabolic characterization of adults with binge eating in the general population: The framingham heart study. (18th August 2014)

• Record Type: Journal Article
• Authors: Abraham, Tobin M.; Massaro, Joseph M.; Hoffmann, Udo; Yanovski, Jack A.; Fox, Caroline S.
• Is Part Of: Obesity. Volume 22:Number 11(2014:Nov.)
• Page Start: 2441
• Page End: 2449
• Publication Date: 2014-08-18
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20867
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20867-sec-0001" sec-type="section"> <title>Objective</title> <p>To describe the metabolic profile of individuals with objective binge eating (OBE) and to evaluate whether associations between OBE and metabolic risk factors are mediated by body mass index (BMI).</p> </sec> <sec id="oby20867-sec-0002" sec-type="section"> <title>Methods</title> <p>Participants from the Framingham Heart Study, Third Generation and Omni 2 cohorts (<italic>n</italic> = 3, 551, 53.1% women, mean age 46.4 years) were screened for binge eating. Multivariable‐adjusted regression models to examine the associations of OBE with metabolic risk factors were used.</p> </sec> <sec id="oby20867-sec-0003" sec-type="section"> <title>Results</title> <p>The prevalence of OBE was 4.8% in women and 4.9% in men. Compared to non‐binge eating, OBE was associated with higher odds of hypertension (OR 1.85, 95% CI 1.32‐2.60), hypertriglyceridemia (OR 1.42, 95% CI 1.01‐2.01), low HDL (OR 1.70, 95% CI 1.18‐2.44), insulin resistance (OR 3.18, 95% CI 2.25‐4.50) and metabolic syndrome (OR 2.75, 95% CI 1.94‐3.90). Fasting glucose was 7.2 mg dl<sup>−1</sup> higher in those with OBE (<italic>P</italic> = 0.0001). Individuals with OBE had more visceral, subcutaneous and liver fat. Most of these associations were attenuated with adjustment for BMI, with the exception of fasting glucose.</p> </sec> <sec id="oby20867-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Binge eating is associated with a high burden of metabolic risk factors. Much of the associated risk appears to be mediated by BMI, with the exception of fasting glucose.</p> </sec> </abstract>