Long‐term hearing loss after chemoradiation in patients with head and neck cancer. (26th June 2014)

• Record Type: Journal Article
• Authors: Theunissen, Eleonoor A. R.; Zuur, Charlotte L.; Bosma, Sophie C. J.; Lopez‐Yurda, Marta; Hauptmann, Michael; van der Baan, Sieberen; de Boer, Jan Paul; van der Molen, Lisette; Rasch, Coen R. N.; Dreschler, Wouter A.; Balm, Alfons J. M.
• Is Part Of: Laryngoscope. Volume 124:Number 12(2014:Dec.)
• Page Start: 2720
• Page End: 2725
• Publication Date: 2014-06-26
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.24802
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary24802-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>The purpose of this study was to determine whether concomitant chemoradiation (CCRT)‐induced hearing loss is progressive over time or not.</p> </sec> <sec id="lary24802-sec-0002" sec-type="section"> <title>Study Design</title> <p>Long‐term (LT) follow‐up study.</p> </sec> <sec id="lary24802-sec-0003" sec-type="section"> <title>Methods</title> <p>Between 1999 and 2004, 158 patients with head and neck cancer were treated with intravenous (IV) CCRT (n = 80) or intraarterial CCRT (n = 78). Audiometry was performed before, short‐term (ST), and LT posttreatment. Differences in hearing were assessed with a multivariable linear regression analysis, incorporating the effect of aging.</p> </sec> <sec id="lary24802-sec-0004" sec-type="section"> <title>Results</title> <p>Long‐term audiometry (median 4.5 years) was available in 67 patients (42%). At ST follow‐up, a deterioration of 21.6 decibel was seen compared to baseline at pure‐tone averages (PTA) 8–10‐12.5 kHz. At LT follow‐up, this deterioration further increased with 5 decibel (<italic>P =</italic> 0.005). Only in CCRT‐IV patients was a significant progressive treatment‐induced hearing loss seen, at PTA 8–10‐12.5 kHz (<italic>P =</italic> 0.005), PTA 1–2‐4 kHz air conduction (<italic>P =</italic> 0.014), and PTA 0.5‐1‐2 kHz bone conduction (<italic>P =</italic> 0.045).</p> </sec> <sec id="lary24802-sec-0005" sec-type="section"> <title>Conclusion</title> <p>CCRT‐induced hearing impairment was progressive over time, especially in higher frequencies and only in CCRT‐IV patients, with a modest deterioration of 5 decibel 4.5 years post‐treatment.</p> </sec> <sec id="lary24802-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p>4. <italic>Laryngoscope</italic>, 124:2720–2725, 2014</p> </sec> </abstract>