Preparation and in vivo evaluation of multifunctional 90Y‐labeled magnetic nanoparticles designed for cancer therapy. Issue 1 (20th March 2014)

• Record Type: Journal Article
• Authors: Radović, Magdalena; Calatayud, María Pilar; Goya, Gerardo Fabián; Ibarra, Manuel Ricardo; Antić, Bratislav; Spasojević, Vojislav; Nikolić, Nadežda; Janković, Drina; Mirković, Marija; Vranješ‐Đurić, Sanja
• Is Part Of: Journal of biomedical materials research. Volume 103:Issue 1(2015:Jan.)
• Page Start: 126
• Page End: 134
• Publication Date: 2014-03-20
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35160
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe<sub>3</sub>O<sub>4</sub>‐Naked (80 ± 5 nm) and polyethylene glycol 600 diacid functionalized Fe<sub>3</sub>O<sub>4</sub> (Fe<sub>3</sub>O<sub>4</sub>‐PEG600) MNPs (46 ± 0.6 nm). They were characterized based on the external morphology, size distribution, and colloidal and magnetic properties. The obtained specific power absorption value for Fe<sub>3</sub>O<sub>4</sub>‐PEG600 MNPs was 200 W/g, indicated their potential in hyperthermia based cancer treatments. The labeling yield, <italic>in vitro</italic> stability and <italic>in vivo</italic> biodistribution profile of <sup>90</sup>Y‐MNPs were compared. Both types of MNPs were <sup>90</sup>Y‐labeled in reproducible high yield (>97%). The stability of the obtained radioactive nanoparticles was evaluated in saline and human serum media in order to optimize the formulations for <italic>in vivo</italic> use. The biodistribution in Wistar rats showed different pharmacokinetic behaviors of nanoparticles: a large fraction of both injected MNPs ended in the liver (14.58%ID/g for <sup>90</sup>Y‐Fe<sub>3</sub>O<sub>4</sub>‐Naked MNPs and 19.61%ID/g for <sup>90</sup>Y‐Fe<sub>3</sub>O<sub>4</sub>‐PEG600 MNPs) whereas minor fractions attained in other organs. The main difference between the two types of MNPs was the higher accumulation of <sup>90</sup>Y‐Fe<sub>3</sub>O<sub>4</sub>‐Naked MNPs in the lungs (12.14%ID/g vs. 2.00%ID/g for <sup>90</sup>Y‐Fe<sub>3</sub>O<sub>4</sub>‐PEG600 MNPs) due to their <italic>in vivo</italic> agglomeration. The studied radiolabeled magnetic complexes such as <sup>90</sup>Y‐Fe<sub>3</sub>O<sub>4</sub>‐PEG600 MNPs constitute a great promise for multiple diagnostic‐therapeutic uses combining, for example, MRI‐magnetic hyperthermia and regional radiotherapy. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 126–134, 2015.</p> </abstract>