Preparation and characterization of electrospun curcumin loaded poly(2‐hydroxyethyl methacrylate) nanofiber—A biomaterial for multidrug resistant organisms. Issue 1 (5th March 2014)

• Record Type: Journal Article
• Authors: Ramalingam, Nithya; Natarajan, T. S.; Rajiv, Sheeja
• Is Part Of: Journal of biomedical materials research. Volume 103:Issue 1(2015:Jan.)
• Page Start: 16
• Page End: 24
• Publication Date: 2014-03-05
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35138
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Curcumin loaded poly(2‐hydroxy ethyl methacrylate) p(HEMA) nanofiber were produced using electrospinning method and characterized. The nanofibrous scaffold supports good cell growth, attachment and retains its original morphology. Sustained and controlled release pattern of curcumin seen to be efficient against infectious disease caused by multidrug resistant organisms. Antibacterial activity of curcumin against Methicillin resistant <italic>staphylococcus aureus</italic> (MRSA) and extended spectrum β lactamase (ESBL) proved to be a good alternate herbal compound for antibiotics. Hence the results indicate p(HEMA) nanofiber loaded with curcumin have potential to use as patch in wound healing of infectious disease caused by multidrug resistant organisms and excellent drug delivery vessel. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 16–24, 2015.</p> </abstract>