Use of a chondroitin sulfate bioadhesive to enhance integration of bioglass particles for repairing critical‐size bone defects. Issue 1 (2nd April 2014)

• Record Type: Journal Article
• Authors: Yang, Shuqing; Guo, Qiongyu; Shores, Lucas S.; Aly, Ahmed; Ramakrishnan, Meera; Kim, Ga Hye; Lu, Qiaozhi; Su, Lixin; Elisseeff, Jennifer H.
• Is Part Of: Journal of biomedical materials research. Volume 103:Issue 1(2015:Jan.)
• Page Start: 235
• Page End: 242
• Publication Date: 2014-04-02
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35143
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Replacement of autogenous or allograft bones by artificial graft materials represents a growing area of interest in current bone repair strategies. Bioactive ceramics in particulate form, such as Bioglass® (BG) 45S5, stimulate bone mineralization comparable to autologous bone grafts, but have potential issues of particle migration and inflammation. The aim of this study was to employ a chondroitin sulfate‐ (CS‐) based bioadhesive to improve integration of the bioglass (NovaBone® Putty) to prevent particle migration and promote bone regeneration. This BG‐CS composite can encapsulate bone marrow (BM) to form a mechanically stable construct, BG‐CS‐BM. Rheological characterization confirmed the formation of CS‐BM hydrogel by reacting the CS‐based bioadhesive with the BM. Compared to the bioglass, the BG‐CS‐BM composite demonstrated a superior capacity to maintain construct integrity under both aqueous and turbulent environments <italic>in vitro</italic>. After implantation for 4 weeks in a critical‐size distal femoral bone defect in a rabbit model, there was significantly greater bone growth in BG‐CS‐BM as compared to bioglass‐only and the empty control. Unlike BG‐CS‐BM, BG‐CS recruited BM <italic>in situ</italic> from the bone defect. BG‐CS demonstrated a similar effect in bone formation but at a comparatively slower rate than BG‐CS‐BM over 6‐weeks' implantation. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 235–242, 2015.</p> </abstract>