New Target Genes in Endometrial Tumors Show a Role for the Estrogen‐Receptor Pathway in Microsatellite‐Unstable Cancers. Issue 12 (December 2014)

• Record Type: Journal Article
• Authors: Ferreira, Ana M.; Tuominen, Iina; Sousa, Sónia; Gerbens, Frans; van Dijk‐Bos, Krista; Osinga, Jan; Kooi, Krista A.; Sanjabi, Bahram; Esendam, Chris; Oliveira, Carla; Terpstra, Peter; Hardonk, Menno; van der Sluis, Tineke; Zazula, Monika; Stachura, Jerzy; van der Zee, Ate G.; Hollema, Harry; Sijmons, Rolf H.; Aaltonen, Lauri A.; Seruca, Raquel; Hofstra, Robert M. W.; Westers, Helga
• Is Part Of: Human mutation. Volume 35:Issue 12(2014:Dec.)
• Page Start: 1514
• Page End: 1523
• Publication Date: 2014-12
• Subjects: Human chromosome abnormalities -- Periodicals; Mutation (Biology) -- Periodicals; 616.04205
• DOI: 10.1002/humu.22700
• Languages: English
• ISSNs: 1059-7794

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="humu22700-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <list id="humu22700-list-0001" list-type="bullet"> <list-item> <p>A genome‐wide search for target genes in endometrial tumors with microsatellite instability.</p> </list-item> <list-item> <p>Seven highy mutated genes were found in endometrial cancer; some of them were also found mutated in colorectal and gastric tumors.</p> </list-item> <list-item> <p>The most mutated gene, <italic>NRIP1</italic>, was silenced in an endometrial cell line, which revealed an association with differences in the expression of several genes in the estrogen‐receptor network.</p> </list-item> </list> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2cpxhwx4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>