Effects of Colistin on the Sensory Nerve Conduction Velocity and F‐wave in Mice. (1st August 2014)

• Record Type: Journal Article
• Authors: Dai, Chongshan; Tang, Shusheng; Li, Jichang; Wang, Jiping; Xiao, Xilong
• Is Part Of: Basic & clinical pharmacology & toxicology. Volume 115:Number 6(2014:Jun.)
• Page Start: 577
• Page End: 580
• Publication Date: 2014-08-01
• Subjects: Pharmacology -- Periodicals; Toxicology -- Periodicals; Pharmacology -- Periodicals; Toxicology -- Periodicals; Pharmacology, Clinical -- Periodicals; Computer network resources; Electronic journals; 615.1
• DOI: 10.1111/bcpt.12272
• Languages: English
• ISSNs: 1742-7835

Abstract

<abstract abstract-type="main" id="bcpt12272-abs-0001"> <title>Abstract</title> <p>The aim of this study was to examine the changes of sensory nerve conduction velocity (SNCV) and F‐wave for colistin‐induced peripheral neurotoxicity using a mouse model. Mice were administered with colistin 5, 7.5 and 15 mg/kg/day via a 3‐min. intravenous infusion. The sensory nerve conduction velocity (SNCV) and F‐wave were measured using the bipolar recording electrodes. The SNCV and F‐wave latency changed in a dose‐ and time‐dependent manner. The significant increase of F‐wave latency and significant decrease of SNCV appeared on day 3 (<italic>p</italic> &lt; 0.05 and 0.01, respectively) in the 15 mg/kg/day group, and they were markedly changed on day 7 in the 7.5 mg/kg/day (<italic>p</italic> &lt; 0.01 and 0.05, respectively) and 15 mg/kg/day groups (both <italic>p</italic> &lt; 0.01). In addition, F‐wave latency also significantly increased on day 7 in the 5 mg/kg/day group (<italic>p</italic> &lt; 0.05) without any clinical signs. These results indicate that SNCV and F‐wave latency were more sensitive in colistin‐induced neurotoxicity in mice, which highlights the early monitoring tool of polymyxins neurotoxicity in the clinic.</p> </abstract>