The risk of newly developed visual impairment in treated normal‐tension glaucoma: 10‐year follow‐up. (3rd April 2014)

• Record Type: Journal Article
• Authors: Choi, Yun Jeong; Kim, Martha; Park, Ki Ho; Kim, Dong Myung; Kim, Seok Hwan
• Is Part Of: Acta ophthalmologica. Volume 92:Number 8(2014)
• Page Start: e644
• Page End: e649
• Publication Date: 2014-04-03
• Subjects: Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.12411
• Languages: English
• ISSNs: 1755-375X

Abstract

<abstract abstract-type="main" id="aos12411-abs-0001"> <title>Abstract</title> <sec id="aos12411-sec-0001" sec-type="section"> <title>Purpose</title> <p>To investigate the risk and risk factors for newly developed visual impairment in treated patients with normal‐tension glaucoma (NTG) followed up on for 10 years.</p> </sec> <sec id="aos12411-sec-0002" sec-type="section"> <title>Methods</title> <p>Patients with NTG, who did not have visual impairment at the initial diagnosis and had undergone intraocular pressure (IOP)‐lowering treatment for more than 7 years, were included on the basis of a retrospective chart review. Visual impairment was defined as either low vision (0.05 [20/400] ≤ visual acuity (VA) <0.3 [20/60] and/or 10 degrees ≤ central visual field (VF) <20 degrees) or blindness (VA <0.05 [20/400] and/or central VF <10 degrees) by World Health Organization (WHO) criteria. To investigate the risk and risk factors for newly developed visual impairment, Kaplan–Meier survival analysis and generalized linear mixed effects models were utilized.</p> </sec> <sec id="aos12411-sec-0003" sec-type="section"> <title>Results</title> <p>During the 10.8 years mean follow‐up period, 20 eyes of 16 patients were diagnosed as visual impairment (12 eyes as low vision, 8 as blindness) among 623 eyes of 411 patients. The cumulative risk of visual impairment in at least one eye was 2.8% at 10 years and 8.7% at 15 years. The risk factors for visual impairment from treated NTG were worse VF mean deviation (MD) at diagnosis and longer follow‐up period.</p> </sec> <sec id="aos12411-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The risk of newly developed visual impairment in the treated patients with NTG was relatively low. Worse VF MD at diagnosis and longer follow‐up period were associated with development of visual impairment.</p> </sec> </abstract>