Combined Magnetic Nanoparticle‐based MicroRNA and Hyperthermia Therapy to Enhance Apoptosis in Brain Cancer Cells. Issue 20 (20th June 2014)

• Record Type: Journal Article
• Authors: Yin, Perry T.; Shah, Birju P.; Lee, Ki‐Bum
• Is Part Of: Small. Volume 10:Issue 20(2014:Oct.)
• Page Start: 4106
• Page End: 4112
• Publication Date: 2014-06-20
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201400963
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="smll201400963-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A novel therapy</bold> is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal‐7a microRNA (let‐7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh2ckx9nxc" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>