Supramolecular inclusion complexes of a star polymer containing cholesterol end‐capped poly(ε‐caprolactone) arms with β‐cyclodextrin. Issue 23 (25th September 2014)

• Record Type: Journal Article
• Authors: Doganci, Erdinc; Gorur, Mesut; Uyanik, Cavit; Yilmaz, Faruk
• Is Part Of: Journal of polymer science. Volume 52:Issue 23(2014:Dec.)
• Page Start: 3406
• Page End: 3420
• Publication Date: 2014-09-25
• Subjects: 547
• DOI: 10.1002/pola.27408
• Languages: English
• ISSNs: 0887-624X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>A novel hexa‐armed and star‐shaped polymer containing cholesterol end‐capped poly(ε‐caprolactone) arms emanating from a phosphazene core (N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub>) was synthesized by a combination of ring‐opening polymerization and "click" chemistry techniques. For this purpose, the terminal OH groups of the synthesized precursor (N<sub>3</sub>P<sub>3</sub>‐(PCL‐OH)<sub>6</sub>) were converted into <italic>–</italic>Chol through a series of reaction. Both N<sub>3</sub>P<sub>3</sub>‐(PCL‐OH)<sub>6</sub> and N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub> were then employed in the preparation of supramolecular inclusion complexes (ICs) with β‐cyclodextrin (β‐CD). The latter formed ICs with β‐CD in higher yield. The host–guest stoichiometry (ε‐CL:β‐CD, mol:mol) in the ICs of N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub> was found to be 1.2. The formation of supramolecular ICs of N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub> with β‐CD was confirmed by using Fourier transform infrared (FTIR) and <sup>1</sup>H nuclear magnetic resonance (NMR) spectroscopic methods, wide‐angle X‐ray diffraction (WAXD), and thermal analysis techniques. WAXD data showed that the obtained ICs with N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub> had a channel‐type crystalline structure, indicating the suppression of the original crystallization of N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub> in β‐CD cavities. Moreover, the thermal stabilities of ICs were found to be higher than those of the free star polymer and β‐CD. Furthermore, the surface properties of N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub> and its ICs with β‐CD were investigated by static contact angle measurements. The obtained results proved that the wettability of N<sub>3</sub>P<sub>3</sub>‐(PCL‐Chol)<sub>6</sub> successfully increased with the formation of its ICs with β‐CD. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. <bold>2014</bold>, <italic>52</italic>, 3406–3420</p> </abstract>