Castor oil–citric acid copolyester for tissue augmentation1. (17th June 2014)

• Record Type: Journal Article
• Authors: Ickowicz, Diana E.; Haim‐Zada, Moran; Abbas, Randa; Touitou, Dan; Nyska, Abraham; Golovanevski, Ludmila; Weiniger, Carolyn F.; Katzhendler, Jeoshua; Domb, Abraham J.; Lendlein, Andreas; Behl, Marc
• Is Part Of: Polymers for advanced technologies. Volume 25:Number 11(2014:Nov.)
• Page Start: 1323
• Page End: 1328
• Publication Date: 2014-06-17
• Subjects: Polymers -- Periodicals; 668.9
• DOI: 10.1002/pat.3345
• Languages: English
• ISSNs: 1042-7147

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Biodegrable polyesters derived from hydroxy acids have a broad clinical use. The aim of the study was to synthesize polymer compositions based on citric acid and castor oil for use as soft tissue augmentation. Two polymers were synthesized, a branched viscous polyester with a monomer ratio of 93.5:6.5 w/w and an apparent molecular weight of 11, 000 Da and a crosslinked semisolid polymer with a monomer ratio of 92.5:7.5 w/w. The branched polymer lost less than 10% of its weight during a 30‐day degradation study. <italic>In vivo</italic> biocompatibility study in rats showed 20% formulation weight loss 9 months post‐subcutaneous administration. These results were in accordance with the <italic>in vitro</italic> hydrolytic degradation of the polymer. The <italic>in vivo</italic> study revealed good tolerability of the copolymer. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>