Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3‐O‐Methyl‐D‐glucose. Issue 5 (18th September 2014)

• Record Type: Journal Article
• Authors: Rivlin, Michal; Tsarfaty, Ilan; Navon, Gil
• Is Part Of: Magnetic resonance in medicine. Volume 72:Issue 5(2014:Nov.)
• Page Start: 1375
• Page End: 1380
• Publication Date: 2014-09-18
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25467
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25467-sec-0001" sec-type="section"> <title>Purpose</title> <p>To evaluate the feasibility to detect tumors and metastases by the chemical exchange saturation transfer (CEST) MRI technique using 3‐O‐Methyl‐D‐glucose (3OMG), a nonmetabolizable derivative of glucose that is taken up rapidly and preferentially by tumors and is entirely excreted by the kidneys.</p> </sec> <sec id="mrm25467-sec-0002" sec-type="section"> <title>Methods</title> <p>In vivo CEST MRI experiments were performed on a Bruker 7 Tesla Biospec on implanted orthotopic mammary tumors of mice before and following i.p. injection of 3OMG. The CEST images were generated by a series of gradient‐echo images collected from a single 1 mm coronal slice after a 1.2 s presaturation pulse, applied at offsets of ±1.2 ppm from the water and at B<sub>1</sub> power of 2.5 µT.</p> </sec> <sec id="mrm25467-sec-0003" sec-type="section"> <title>Results</title> <p>Following 3OMG (1.5 g/kg) i.p. injection, an enhanced CEST effect of approximately 20% was visualized at the tumor within a few minutes. The signal slowly declined reaching half of its maximum at approximately 80 min.</p> </sec> <sec id="mrm25467-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Due to the large CEST effect of 3OMG and its low toxicity 3OMG‐CEST may serve for the detection of tumors and metastases in the clinic. Magn Reson Med 72:1375–1380, 2014. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>