Coordinated reset neuromodulation for Parkinson's disease: Proof‐of‐concept study. Issue 13 (28th June 2014)

• Record Type: Journal Article
• Authors: Adamchic, Ilya; Hauptmann, Christian; Barnikol, Utako Brigit; Pawelczyk, Norbert; Popovych, Oleksandr; Barnikol, Thomas Theo; Silchenko, Alexander; Volkmann, Jens; Deuschl, Günter; Meissner, Wassilios G; Maarouf, Mohammad; Sturm, Volker; Freund, Hans‐Joachim; Tass, Peter Alexander
• Is Part Of: Movement disorders. Volume 29:Issue 13(2014)
• Page Start: 1679
• Page End: 1684
• Publication Date: 2014-06-28
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25923
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="mds25923-sec-0001" sec-type="section"> <title>Background</title> <p>The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony.</p> </sec> <sec id="mds25923-sec-0002" sec-type="section"> <title>Methods</title> <p>In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments.</p> </sec> <sec id="mds25923-sec-0003" sec-type="section"> <title>Results</title> <p>Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function.</p> </sec> <sec id="mds25923-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high‐frequency deep brain stimulation in PD. © 2014 The Authors. <italic>Movement</italic> Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.</p> </sec> </abstract>