Cytoskeleton of newborn vocal fold stellate cells. (13th June 2014)

• Record Type: Journal Article
• Authors: Sato, Kiminori; Kurita, Takashi; Chitose, Shun‐ichi; Umeno, Hirohito; Nakashima, Tadashi
• Is Part Of: Laryngoscope. Volume 124:Number 11(2014:Nov.)
• Page Start: 2551
• Page End: 2554
• Publication Date: 2014-06-13
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.24776
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary24776-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>Vocal fold stellate cells (VFSCs) in the human maculae flavae located at both ends of the vocal fold mucosa are inferred to be involved in the metabolism of extracellular matrices of the vocal fold mucosa. Tension caused by phonation (vocal fold vibration) likely regulates the behavior of the VFSCs in the human maculae flava. Tensile and compressive strains have direct effects on cell morphology and structure, including changes in cytoskeletal structure and organization. Cytoskeletons play a role as mechanoreceptors for the cells.</p> <p>The microstructure of the intermediate filaments and the expression of their characteristic proteins were investigated regarding the human newborn VFSCs.</p> </sec> <sec id="lary24776-sec-0002" sec-type="section"> <title>Study Design</title> <p>Histopathologic analysis of the human newborn vocal fold.</p> </sec> <sec id="lary24776-sec-0003" sec-type="section"> <title>Methods</title> <p>Three newborn vocal fold mucosae were investigated by immunohistochemistry and electron microscopy.</p> </sec> <sec id="lary24776-sec-0004" sec-type="section"> <title>Results</title> <p>The intermediate filaments in the cytoplasm of the newborn VFSCs were few in number. However, their characteristic proteins (vimentin, desmin, GFAP [Glial fibrillary acidic protein], cytokeratin) had already expressed.</p> </sec> <sec id="lary24776-sec-0005" sec-type="section"> <title>Conclusion</title> <p>The function and fate of VFSCs are regulated by various microenvironmental factors. Not only chemical factors but also mechanical factors could also modulate VFSC behaviors. The cytoskeletal structure of the newborn VFSCs is under development. And the newborn VFSCs have not acquired mechanical regulation.</p> </sec> <sec id="lary24776-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p>N/A. <italic>Laryngoscope</italic>, 124:2551–2554, 2014</p> </sec> </abstract>