Epithelial to mesenchymal transition correlates with tumor budding and predicts prognosis in esophageal squamous cell carcinoma. Issue 6 (29th June 2014)

• Record Type: Journal Article
• Authors: Niwa, Yukiko; Yamada, Suguru; Koike, Masahiko; Kanda, Mitsuro; Fujii, Tsutomu; Nakayama, Goro; Sugimoto, Hiroyuki; Nomoto, Shuji; Fujiwara, Michitaka; Kodera, Yasuhiro
• Is Part Of: Journal of surgical oncology. Volume 110:Issue 6(2014:Nov. 01)
• Page Start: 764
• Page End: 769
• Publication Date: 2014-06-29
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23694
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23694-sec-0001" sec-type="section"> <title>Background and Objectives</title> <p>Epithelial to mesenchymal transition (EMT) is considered to play an important role in cancer invasion. Tumor budding is a prognostic factor in esophageal squamous cell carcinoma (ESCC). The aim of this study was to explore the correlation between EMT and tumor budding.</p> </sec> <sec id="jso23694-sec-0002" sec-type="section"> <title>Methods</title> <p>Surgical specimens from 78 cases of ESCC resected without preoperative treatment between 2001 and 2013 were enrolled in the study. The mRNA expressions of E‐cadherin and vimentin were measured in cancerous tissues using real‐time PCR, and each tumor was classified into either epithelial or mesenchymal group. Tumor budding was evaluated in H&E‐stained slides and divided into two groups; low‐grade budding (<3) and high‐grade budding (≥3).</p> </sec> <sec id="jso23694-sec-0003" sec-type="section"> <title>Results</title> <p>The 5‐year survival rate in the epithelial group was significantly higher than that in the mesenchymal group (62.0% vs. 31.5%, <italic>P</italic> = 0.021). Survival rate of patients in the low‐grade budding group was significantly higher than that of patients in the high‐grade budding group (75.1% vs. 25.9%, <italic>P</italic> < 0.001). High‐grade tumor budding was significantly associated with the mesenchymal group (<italic>P</italic> = 0.009).</p> </sec> <sec id="jso23694-sec-0004" sec-type="section"> <title>Conclusion</title> <p>EMT was found to occur in ESCC and was significantly associated with tumor budding. Tumor budding was identified as a significant independent prognostic factor among the current population of ESCC. <italic>J. Surg. Oncol. 2014 110:764–769</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>