Prognostic significance of the intratumoral heterogeneity of 18F‐FDG uptake in oral cavity cancer. Issue 6 (29th June 2014)

• Record Type: Journal Article
• Authors: Kwon, Soo Hyun; Yoon, Joon‐Kee; An, Young‐Sil; Shin, Yoo Seob; Kim, Chul‐Ho; Lee, Dong Hyun; Jo, Kyung Sook; Lee, Su Jin
• Is Part Of: Journal of surgical oncology. Volume 110:Issue 6(2014:Nov. 01)
• Page Start: 702
• Page End: 706
• Publication Date: 2014-06-29
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23703
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>ABSTRACT</title> <sec id="jso23703-sec-0001" sec-type="section"> <title>Backgrounds</title> <p>We evaluated the prognostic value of the intratumoral heterogeneity of <sup>18</sup>F‐FDG uptake in oral cavity cancer.</p> </sec> <sec id="jso23703-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>We enrolled 45 patients who underwent pretreatment <sup>18</sup>F‐FDG PET/CT. The intratumoral heterogeneity of <sup>18</sup>F‐FDG uptake was represented as the heterogeneity factor (HF), defined as the derivative (dV/dT) of a volume‐threshold function for a primary tumor. We measured the maximum standardized uptake value (SUV<sub>max</sub>) and volumetric PET parameters. The relationship between HF and clinical parameters, as well as other PET parameters, was evaluated.</p> </sec> <sec id="jso23703-sec-0003" sec-type="section"> <title>Results</title> <p>The HF was significantly correlated with SUV<sub>max</sub> (r = −0.353, <italic>P</italic> = 0.017), metabolic tumor volume (r = −0.708, <italic>P</italic> < 0.0001), and total lesion glycolysis (r = −0.709, <italic>P</italic> < 0.0001). A multivariate analysis revealed not only cervical lymph node metastasis (hazard ratio = 5.983; <italic>P</italic> = 0.022) but also HF (hazard ratio = 2.49 × 10<sup>−4</sup>; <italic>P</italic> = 0.002) to be independent predictors of overall survival. Those patients with HF < −0.13 showed a worse prognosis than those with HF ≥ −0.13 (<italic>P</italic> = 0.005).</p> </sec> <sec id="jso23703-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The intratumoral heterogeneity of <sup>18</sup>F‐FDG uptake may be a significant prognostic factor for overall survival in addition to cervical lymph node metastasis in oral cavity cancer. <italic>J. Surg. Oncol. 2014 110:702–706</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>