Clinical values of 18F‐FDG PET/CT in oral cavity cancer with dental artifacts on CT or MRI. Issue 6 (3rd July 2014)

• Record Type: Journal Article
• Authors: Hong, Hye Ran; Jin, Soyoung; Koo, Hyun Jung; Roh, Jong‐Lyel; Kim, Jae Seung; Cho, Kyung‐Ja; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon
• Is Part Of: Journal of surgical oncology. Volume 110:Issue 6(2014:Nov. 01)
• Page Start: 696
• Page End: 701
• Publication Date: 2014-07-03
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23691
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23691-sec-0001" sec-type="section"> <p> <bold>Level of Evidence:</bold> 2a</p> <p> <bold>Background and Objectives:</bold> To investigate the role of <sup>18</sup>F‐FDG PET/CT in tumor staging, extent, and volume measurements in oral cavity squamous cell carcinoma (OSCC) patients with/without dental artifacts on CT or MRI.</p> <p> <bold>Methods:</bold> This study was conducted in 63 consecutive patients with OSCC who received initial workups including <sup>18</sup>F‐FDG PET/CT and MRI. The results of the imaging modalities were compared to those of pathology, using McNemar's test and the paired <italic>t</italic>‐test.</p> <p> <bold>Results:</bold> Thirty‐seven patients (59%) had dental or metallic artifacts obscuring primary tumors. <sup>18</sup>F‐FDG PET/CT scanning was superior to MRI in tumor staging (weighted κ = 0.870 vs. 0.518, <italic>P</italic> = 0.004) in patients with dental artifacts. In addition, <sup>18</sup>F‐FDG PET/CT scans were more specific than MRI in detecting sublingual gland (<italic>P</italic> = 0.014) and mouth floor (<italic>P</italic> = 0.011) involvement. In patients with dental artifacts, there was a significant discrepancy between primary tumor volume (PTV) measured by pathology and MRI (<italic>P</italic> = 0.018), but not between PTV measured from pathology and <sup>18</sup>F‐FDG PET/CT at SUV2.5 (<italic>P</italic> = 0.245), which showed the highest intraclass correlation coefficient value (0.860).</p> <p> <bold>Conclusion:</bold> <sup>18</sup>F‐FDG PET/CT scans provide accurate tumor staging and volume measurements in OSCC patients with CR/MRI dental artifacts, leading to improved preoperative planning.</p> <p> <bold>Level of Evidence:</bold> 2b</p> <p>CONDENSED ABSTRACT</p> <p>This study evaluated the clinical value of <sup>18</sup>F‐FDG PET/CT in 63 patients with oral cavity cancers. In 37 (59%) patients with dental artifacts on CT/MRI, <sup>18</sup>F‐FDG PET/CT showed superior results compared to MRI in tumor staging and represented the highest intraclass correlation coefficient value to tumor volume determined by pathology. <italic>J. Surg. Oncol. 2014 110:696–701</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>