Examination of national lymph node evaluation practices for adult extremity soft tissue sarcoma. Issue 6 (7th June 2014)

• Record Type: Journal Article
• Authors: Sherman, Karen L.; Kinnier, Christine V.; Farina, Domenico A.; Wayne, Jeffrey D.; Laskin, William B.; Agulnik, Mark; Attar, Samer; Hayes, John P.; Peabody, Terrance; Bilimoria, Karl Y.
• Is Part Of: Journal of surgical oncology. Volume 110:Issue 6(2014:Nov. 01)
• Page Start: 682
• Page End: 688
• Publication Date: 2014-06-07
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23687
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23687-sec-0001" sec-type="section"> <title>Background and Objectives</title> <p>Lymph node evaluation recommendations for extremity soft tissue sarcoma (ESTS) are absent from national guidelines. Our objectives were (1) to assess rates and predictors of nodal evaluation, and (2) to assess rates and predictors of nodal metastases.</p> </sec> <sec id="jso23687-sec-0002" sec-type="section"> <title>Methods</title> <p>ESTS patients from the National Cancer Data Base (2000–2009) were assessed, and regression models were used to identify factors associated with nodal evaluation and metastases.</p> </sec> <sec id="jso23687-sec-0003" sec-type="section"> <title>Results</title> <p>Of 27, 536 ESTS patients, 1, 924 (7%) underwent nodal evaluation, and of these, 290 (15%) had nodal metastases. Nodal evaluation was most frequently performed for rhabdomyosarcoma (15.6%), angiosarcoma (10.0%), clear cell sarcoma (39.3%), epithelioid sarcoma (28.1%), and synovial sarcoma (9.3%). On multivariable analysis, factors associated with nodal evaluation included histologic subtype, tumor size, and grade. Nodal metastasis rates were highest among patients with rhabdomyosarcoma (32.1%), angiosarcoma (24.1%), clear cell sarcoma (27.7%), and epithelioid sarcoma (31.8%). On multivariable analysis, factors associated with nodal metastases included histologic subtype, tumor size, and grade.</p> </sec> <sec id="jso23687-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Nodal evaluation rates are highest among certain expected subtypes but are generally low. However, nodal metastasis rates for many histologic subtypes in patients selected for lymph node evaluation may be higher than previously reported. Multi‐institutional studies should address nodal evaluation for ESTS. <italic>J. Surg. Oncol. 2014 110:682–688</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>