Clinical significance of pretreatment metabolic tumor volume and total lesion glycolysis in hypopharyngeal squamous cell carcinomas. Issue 7 (2nd August 2014)

• Record Type: Journal Article
• Authors: Roh, Jong‐Lyel; Kim, Jae Seung; Kang, Byung Chul; Cho, Kyung‐Ja; Lee, Sang‐wook; Kim, Sung‐Bae; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon
• Is Part Of: Journal of surgical oncology. Volume 110:Issue 7(2014:Dec. 01)
• Page Start: 869
• Page End: 875
• Publication Date: 2014-08-02
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23729
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>ABSTRACT</title> <sec id="jso23729-sec-0001" sec-type="section"> <title>Background</title> <p>To evaluate the usefulness of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by pretreatment fluorine 18‐fluorodeoxyglucose (<sup>18</sup>F‐FDG) positron emission tomography (PET)/computed tomography (CT) as predictors of clinical outcome in hypopharyngeal squamous cell carcinoma (HPSCC).</p> </sec> <sec id="jso23729-sec-0002" sec-type="section"> <title>Methods</title> <p>Seventy‐eight patients with HPSCC treated with definitive radiotherapy with or without chemotherapy underwent <sup>18</sup>F‐FDG PET/CT. Maximum standardized uptake value (SUV<sub>max</sub>), MTV, and TLG were measured. For calculation of MTV, 3‐D regions of interest were drawn and a SUV threshold of 2.5 was used for defining region. Univariate and multivariate analyses identified variables associated with disease‐free survival (DFS) and overall survival (OS).</p> </sec> <sec id="jso23729-sec-0003" sec-type="section"> <title>Results</title> <p>Median SUV<sub>max</sub>, MTV, and TLG were 9.0 (range, 1.7–24.5), 20.5 (0.3–339.9) ml, and 98.9 (0.8–1877.1) g, respectively. The four‐year DFS and OS were 56.1% and 52.6%, respectively. On univariate and multivariate analyses, MTV (P = 0.014) and TLG (<italic>P</italic> = 0.029) were independent prognostic factors for DFS, and MTV (<italic>P</italic> = 0.002) and TLG (<italic>P</italic> = 0.002) were independent prognostic factors for OS.</p> </sec> <sec id="jso23729-sec-0004" sec-type="section"> <title>Conclusion</title> <p>MTV and TLG measured by pretreatment <sup>18</sup>F‐FDG PET/CT may be useful in predicting the clinical outcomes of HPSCC patients undergoing radiotherapy. <italic>J. Surg. Oncol. 2014 110:869–875</italic>. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>