Reproducibility of MRI renal artery blood flow and BOLD measurements in patients with chronic kidney disease and healthy controls. Issue 5 (5th November 2013)

• Record Type: Journal Article
• Authors: Khatir, Dinah S.; Pedersen, Michael; Jespersen, Bente; Buus, Niels H.
• Is Part Of: Journal of magnetic resonance imaging. Volume 40:Issue 5(2014)
• Page Start: 1091
• Page End: 1098
• Publication Date: 2013-11-05
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24446
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24446-sec-0001" sec-type="section"> <title>Purpose</title> <p>Determine the reproducibility of renal artery blood flow (RABF) and blood‐oxygenation level dependent (R<sub>2</sub>*) in patients with chronic kidney disease (CKD) and healthy controls.</p> </sec> <sec id="jmri24446-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>RABF and R<sub>2</sub>* were measured in 11 CKD patients and 9 controls twice with 1‐ to 2‐week interval. R<sub>2</sub>* in the cortex and medulla were determined after breathing atmospheric air and 100% oxygen. Reproducibility was evaluated by coefficients of variation (CV), limits of agreements and intra‐class coefficient calculated by variance components by maximum likelihood modeling.</p> </sec> <sec id="jmri24446-sec-0003" sec-type="section"> <title>Results</title> <p>Single‐kidney RABF (mL/min) for patients was: 170 ± 130 and 186 ± 137, and for controls: 365 ± 119 and 361 ± 107 (<italic>P</italic> < 0.05 versus patients), for first and second scans, respectively. RABF measurements were reproducible with a CV of 12.9% and 8.3% for patients and controls, respectively. Renal cortical R<sub>2</sub>* was: 13.6 ± 0.9 and 13.5 ± 1.2 in patients (CV = 8.0%), and 13.8 ± 1.6 and 14.0 ± 1.5 in controls (CV = 5.6%), while medullary R<sub>2</sub>*(s<sup>−1</sup>) was: 26.9 ± 2.0 and 27.0 ± 4.0 (CV = 8.0%) in patients, and 26.0 ± 2.4 and 26.1 ± 2.1 (CV = 3.6%) in controls, for first and second scans, respectively. In both groups R<sub>2</sub>* in medulla decreased after breathing 100% oxygen.</p> </sec> <sec id="jmri24446-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The reproducibility was high for both RABF and R<sub>2</sub>* in patients and controls, particularly in the cortex. Inhalation of 100% oxygen reduced medullary R<sub>2</sub>*. <bold>J. Magn. Reson. Imaging 2014;40:1091–1098</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>