The synthesis of 14C‐labeled N‐succinimidyl‐3‐maleimidopropionate, a linker molecule for PEGylated biologics. (10th October 2014)

• Record Type: Journal Article
• Authors: Cao, Kai; Maxwell, Brad D.; Bonacorsi, Samuel J.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 57:Number 12(2014)
• Page Start: 667
• Page End: 669
• Publication Date: 2014-10-10
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3225
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Carbon‐14 labeled linker molecule, <italic>N</italic>‐succinimidyl‐3‐maleimidopropionate was prepared for disposition studies of PEGylated biologics. Our new route started with 100 mCi of carbon‐14 labeled Potassium cyanide (KCN) to prepare 55 mCi of [1‐¹⁴C]<italic>N</italic>‐succinimidyl‐3‐maleimidopropionate, 6 in five steps. This represents a multiple of 5.5× improvement in the yield of the desired labeled product compared with our previous synthesis.</p> </abstract>