Response to chemotherapy in gastric adenocarcinoma with diffusion‐weighted MRI and 18F‐FDG‐PET/CT: Correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade. Issue 5 (8th November 2013)

• Record Type: Journal Article
• Authors: Giganti, Francesco; De Cobelli, Francesco; Canevari, Carla; Orsenigo, Elena; Gallivanone, Francesca; Esposito, Antonio; Castiglioni, Isabella; Ambrosi, Alessandro; Albarello, Luca; Mazza, Elena; Gianolli, Luigi; Staudacher, Carlo; Del Maschio, Alessandro
• Is Part Of: Journal of magnetic resonance imaging. Volume 40:Issue 5(2014)
• Page Start: 1147
• Page End: 1157
• Publication Date: 2013-11-08
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24464
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24464-sec-0001" sec-type="section"> <title>Purpose</title> <p>To assess whether changes in diffusion‐weighted MRI (DW‐MRI) and <sup>18</sup>F‐fluoro‐2‐deoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F‐FDG PET/CT), correlate with treatment response to neoadjuvant therapy (NT), as expressed by tumor regression grade (TRG), from locally advanced gastric adenocarcinoma (GA).</p> </sec> <sec id="jmri24464-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Seventeen patients underwent both DW‐MRI and <sup>18</sup>F‐FDG‐PET/CT scans before and after the end of NT. Apparent diffusion coefficient (ADC) and mean standardized uptake value (SUV) corrected for partial volume effect (PVC‐SUV<sub>BW‐mean</sub>) were evaluated and compared with histopathological TRG.</p> </sec> <sec id="jmri24464-sec-0003" sec-type="section"> <title>Results</title> <p>Pre‐ and post‐NT and percentage changes for ADC and PVC‐SUV<sub>BW‐mean</sub> were assessed. Post‐NT ADC and ΔADC showed a significant inverse correlation with TRG (<italic>r</italic> = −0.71; <italic>P</italic> = 0.0011 and <italic>r</italic> = −0.78; <italic>P</italic> = 0.00020, respectively) and significant differences in their mean values were found between responders (TRG 1–2‐3) and nonresponders (TRG 4–5) (<italic>P</italic> = 0.0009; <italic>P</italic> = 0.000082, respectively). No correlations with TRG were found for pre‐NT ADC and for all PVC‐SUV<sub>BW‐mean</sub> values as well as between ΔADC and Δ PVC‐SUV<sub>BW‐mean</sub>.</p> </sec> <sec id="jmri24464-sec-0004" sec-type="section"> <title>Conclusion</title> <p>DW‐MRI seems more accurate than <sup>18</sup>F‐FDG‐PET/CT and ADC modifications may represent a reproducible tool to assess tumor response for GA. <bold>J. Magn. Reson. Imaging 2014;40:1147–1157</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>