A microwave radiosynthesis of the 4‐[18F]‐fluorobenzyltriphenylphosphonium ion. (20th October 2014)

• Record Type: Journal Article
• Authors: Ravert, Hayden T.; Holt, Daniel P.; Dannals, Robert F.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 57:Number 12(2014)
• Page Start: 695
• Page End: 698
• Publication Date: 2014-10-20
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3241
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The 4‐[¹⁸F]‐fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [¹⁸F]‐fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4‐[¹⁸F]‐fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/µmole at end of synthesis.</p> </abstract>