Synthesis and Fungicidal Activity of (E)‐α‐(Methoxyimino)benzeneacetate Derivatives Containing 1, 2, 4‐Triazole Schiff Base Side Chain. (17th March 2014)

• Record Type: Journal Article
• Authors: Song, Hong‐Xing; Shi, De‐Qing
• Is Part Of: Journal of heterocyclic chemistry. Volume 51:Number 5(2014)
• Page Start: 1345
• Page End: 1348
• Publication Date: 2014-03-17
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.1795
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>To find new strobilurin analogs with high activity against resistant pathogens, twelve (<italic>E</italic>)‐α‐(methoxyimino)benzeneacetate derivatives containing 1, 2, 4‐triazole Schiff base side chain <bold>3a</bold>, <bold>3b</bold>, <bold>3c</bold>, <bold>3d</bold>, <bold>3e</bold>, <bold>3f</bold>, <bold>3g</bold>, <bold>3h</bold>, <bold>3i</bold>, <bold>3j</bold>, <bold>3k</bold>, <bold>3l</bold> were designed and synthesized. Their structures were confirmed by IR, ¹H‐NMR, EIMS, and elemental analyses. Bioassays indicated that most of the target compounds showed moderate to good fungicidal activities against <italic>Physalospora piricola Nose</italic> and <italic>Alternaria solani</italic>. For example, compounds <bold>3d</bold>, <bold>3e</bold>, and <bold>3f</bold> possessed 99.5%, 100%, and 95.6% inhibition against <italic>Physalospora piricola Nose</italic>, whereas compounds <bold>3d</bold>, <bold>3f</bold>, and <bold>3g</bold> exhibited 92%, 91%, and 92% inhibition against <italic>Alternaria solani</italic> at the concentration of 50 mg/L, respectively.</p> </abstract>