The role of postnatal neurogenesis in supporting remote memory and spatial metric processing. Issue 12 (27th August 2014)

• Record Type: Journal Article
• Authors: Kesner, Raymond P.; Hui, Xu; Sommer, Taylor; Wright, Casey; Barrera, Vanessa R.; Fanselow, Michael S.
• Is Part Of: Hippocampus. Volume 24:Issue 12(2014:Dec.)
• Page Start: 1663
• Page End: 1671
• Publication Date: 2014-08-27
• Subjects: Hippocampus (Brain) -- Periodicals; 612.825
• DOI: 10.1002/hipo.22346
• Languages: English
• ISSNs: 1050-9631

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>In this study, we determined the contribution of juvenile neurogenesis to the performance of mice on a remote memory for temporally based association task and in a novelty based spatial pattern separation task. This was accomplished by mating homozygous DNMT1‐loxP mice with heterozygous GFAP‐Cre mice and comparing Cre+ (no postnatal neurogenesis) to Cre− (wild type) littermate offspring. The results indicate that Cre+ mice are impaired relative to Cre− mice in the remote memory for a temporal based association task and in a novelty based spatial pattern separation task. These results support the temporal integration model of Aimone et al., [(2006) Nat Neurosci 9:723–727] and provide further support for an important role for postnatally born neurons in spatial pattern separation. In contrast, Cre+ mice are not impaired relative to Cre− mice in an object‐context recognition task and a spatial location recognition task. These latter data suggest that postnatally derived neurons in the dentate gyrus (DG) do not support all spatial and object recognition functions of the DG. © 2014 Wiley Periodicals, Inc.</p> </abstract>